Functional brain hyper-activations are linked to an electrophysiological measure of slow inter-hemispheric transfer time after pediatric moderate/severe traumatic brain injury.

Clicks: 359
ID: 28370
2019
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Emerging

Ranked #8 of 40 articles by views in journal of neurotrauma

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
Increased task-related blood oxygen level dependent (BOLD) activation is commonly observed in fMRI studies of moderate/severe traumatic brain injury (msTBI) but the functional relevance of these hyper-activations and how they are linked to more direct measures of neuronal function remains largely unknown. Here we investigated how working memory load (WML)-dependent BOLD activation was related to an electrophysiological measure of inter-hemispheric transfer time (IHTT) in a sample of 18 msTBI patients and 26 demographically matched controls from the UCLA Recovery after Pediatric Brain Injury (RAPBI) study. In the context of highly similar fMRI task performance, a sub-group of TBI patients with slow IHTT had greater BOLD activation with higher WML than both healthy control children and a subgroup of msTBI patients with normal IHTT. Slower IHTT included as a continuous variable was also associated with BOLD hyper-activation in the full TBI sample and in controls. Higher WML dependent BOLD activation was related to better performance on a clinical cognitive performance index, an association that was more pronounced within the patient group with slow IHTT. Our prior work has shown that a sub-group of children with slow IHTT after pediatric msTBI has increased risk for poor white matter organization, long-term neurodegeneration, and poor cognitive outcome. BOLD hyper-activations after msTBI may reflect neuronal compensatory processes supporting higher order capacity demanding cognitive functions in the context of inefficient neuronal transfer of information. The link between BOLD hyper-activations and slow IHTT adds to the multimodal validation of this electrophysiological measure as a promising biomarker.
Reference Key
olsen2019functionaljournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Olsen, Alexander;Babikian, Talin;Dennis, Emily;Ellis-Blied, Monica U;Giza, Christopher C;Marion, Sarah DeBoard;Mink, Richard;Johnson, Jeffrey;Babbitt, Christopher;Thompson, Paul;Asarnow, Robert F;
Journal journal of neurotrauma
Year 2019
DOI
10.1089/neu.2019.6532
URL
Keywords Keywords not found

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.