The relationship of inflammatory markers NLR and PLR with HbA1c in Turkish diabetic patients.

As inflammation plays a role in the pathogenesis of DM, we aimed to show the relationship between the best indicator of DM-HbA1c levels and inflammatory parameters Neutrophil-to-Lymphocyte Ratio (NLR) and Platelet-to-Lymphocyte Ratio (PLR) in the present study. This study was conducted in December 2023 at Ankara Bilkent Training and Research Hospital Clinical Biochemistry Department with a total of 136 participants. The data were analyzed with SPSS for Windows, Version 22, and Microsoft Excel 365. In the study, the subjects were divided into three groups according to their HbA1c levels: DM group (HbA1c ≥ 6.5 %), Pre-DM group (HbA1c ≥ 5.7 and < 6.5 %), and control group (HbA1c < 5.7 %). The NLR values were statistically different in control between the T2DM patients and control group and the T2DM patients and Pre-DM people (p = 0.025), (p = 0.034) respectively. The platelet and PLR levels were not statistically significant in group comparisons. In light of our findings, we propose a greater emphasis on routinely measuring inflammatory markers, such as NLR, in order to evaluate the glycemic control in patients with type 2 diabetes. We suggest that inflammatory marker-based approaches may be useful to monitor disease progression and maximize treatment outcomes in type 2 diabetes.