A Review of Phytochemical and Pharmacological Studies on L., Rubiaceae.

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ID: 282411
2025
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Abstract
(Yellow Bedstraw) is a rhizomatous perennial herb belonging to the Rubiaceae family. It is native to Eurasia and Africa but has also been introduced to southern Canada and the northern U.S. Widely used in traditional medicine, has been recognized for its diuretic, anti-inflammatory, antimicrobial, analgesic, and anticancer properties. Phytochemical studies have shown that the plant is rich in significant bioactive compounds, such as flavonoids, phenolic acids, iridoids, anthraquinones, phytosterols, coumarins, and tannins. Research suggests that exhibits strong antioxidant activity, protecting cells from oxidative stress and inflammation. Its antimicrobial potential has been demonstrated against various bacterial and fungal pathogens, supporting its traditional use in wound healing and infection treatment. Moreover, modern studies indicate its cytotoxic effects on cancer cells, suggesting potential applications in oncology. Additionally, its hepatoprotective and neuroprotective properties highlight its promise for treating metabolic and neurodegenerative disorders. Despite its well-known therapeutic potential, further studies are required to fully clarify its mechanisms of action and ensure its safety for medicinal use. Given the variety of bioactive compounds found in and their pharmacological benefits, this review emphasizes the importance of this species as a valuable medicinal plant, encouraging further scientific research for its application in pharmacology.
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petkova2025a Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Petkova, Margarita Koleva; Grozeva, Neli Hristova; Tzanova, Milena Tankova; Todorova, Mima Hristova
Journal molecules
Year 2025
DOI
10.3390/molecules30081856
URL
Keywords
Phytochemistry flavonoids antioxidants biological activity phenols pharmacology iridoids rubiaceae galium verum l.

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