The Vitamin D Receptor (VDR) Gene Polymorphisms in Turkish Brain Cancer Patients

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ID: 28136
2013
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Abstract
Objective. It has been stated that brain cancers are an increasingly serious issue in many parts of the world. The aim of our study was to determine a possible relationship between Vitamin D receptor (VDR) gene polymorphisms and the risk of glioma and meningioma. Methods. We investigated the VDR Taq-I and VDR Fok-I gene polymorphisms in 100 brain cancer patients (including 44 meningioma cases and 56 glioma cases) and 122 age-matched healthy control subjects. This study was performed by polymerase chain reaction-based restriction fragment length polymorphism (RF LP). Results. VDR Fok-I ff genotype was significantly increased in meningioma patients (15.9%) compared with controls (2.5%), and carriers of Fok-I ff genotype had a 6.47-fold increased risk for meningioma cases. There was no significant difference between patients and controls for VDR Taq-I genotypes and alleles. Conclusions. We suggest that VDR Fok-I genotypes might affect the development of meningioma.
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toptas2013thebiomed Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Toptaş, Bahar;Kafadar, Ali Metin;Cacina, Canan;Turan, Saime;Yurdum, Leman Melis;Yiğitbaşı, Nihal;Gökçe, Muhammed Oğuz;Zeybek, Ümit;Yaylım, Ilhan;
Journal BioMed research international
Year 2013
DOI
DOI not found
URL
http://dx.doi.org/10.1155/2013/295791
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