Lipidomic signatures align with inflammatory patterns and outcomes in critical illness.

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ID: 278389
2022
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Abstract
Alterations in lipid metabolism have the potential to be markers as well as drivers of pathobiology of acute critical illness. Here, we took advantage of the temporal precision offered by trauma as a common cause of critical illness to identify the dynamic patterns in the circulating lipidome in critically ill humans. The major findings include an early loss of all classes of circulating lipids followed by a delayed and selective lipogenesis in patients destined to remain critically ill. The previously reported survival benefit of early thawed plasma administration was associated with preserved lipid levels that related to favorable changes in coagulation and inflammation biomarkers in causal modelling. Phosphatidylethanolamines (PE) were elevated in patients with persistent critical illness and PE levels were prognostic for worse outcomes not only in trauma but also severe COVID-19 patients. Here we show selective rise in systemic PE as a common prognostic feature of critical illness.
Reference Key
wu2022lipidomicnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wu, Junru;Cyr, Anthony;Gruen, Danielle S;Lovelace, Tyler C;Benos, Panayiotis V;Das, Jishnu;Kar, Upendra K;Chen, Tianmeng;Guyette, Francis X;Yazer, Mark H;Daley, Brian J;Miller, Richard S;Harbrecht, Brian G;Claridge, Jeffrey A;Phelan, Herb A;Zuckerbraun, Brian S;Neal, Matthew D;Johansson, Pär I;Stensballe, Jakob;Namas, Rami A;Vodovotz, Yoram;Sperry, Jason L;Billiar, Timothy R;, ;
Journal Nature communications
Year 2022
DOI
6789
URL
Keywords
child health caregivers implementation child nutrition disease prevention training of trainers intervention programming service and outcomes

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