Individual target pharmacokinetic/pharmacodynamic attainment rates among meropenem-treated patients admitted to the ICU with hospital-acquired pneumonia.

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ID: 278099
2022
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Abstract
Critical illness reduces β-lactam pharmacokinetic/pharmacodynamic (PK/PD) attainment. We sought to quantify PK/PD attainment in patients with hospital-acquired pneumonia.Meropenem plasma PK data (n = 70 patients) were modelled, PK/PD attainment rates were calculated for empirical and definitive targets, and between-patient variability was quantified [as a coefficient of variation (CV%)].Attainment of 100% T>4×MIC was variable for both empirical (CV% = 92) and directed (CV% = 33%) treatment.Individualization is required to achieve suggested PK/PD targets in critically ill patients.
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Authors Rohani, Roxane;Scheetz, Marc H;Donnelly, Helen K;Donayre, Alvaro;Kang, Mengjia;Diaz, Estefani;Dedicatoria, Kay;Hauser, Alan R;Ozer, Egon A;Nozick, Sophia;Qi, Chao;Pawlowski, Anna E;Neely, Michael N;Misharin, Alexander V;Wunderink, Richard G;Rhodes, Nathaniel J;, ;
Journal The Journal of antimicrobial chemotherapy
Year 2022
DOI
10.1093/jac/dkac245
URL
Keywords
hospital-acquired pneumonia maximum-accuracy predictive model pharmacokinetics, pharmacodynamics

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