Activated Microglia in the Early Stage of a Rat Model of Parkinson's Disease: Revealed by PET-MRI Imaging by [F]DPA-714 Targeting TSPO.
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ID: 276648
2023
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Abstract
In the past decades, translocator protein (TSPO) has been considered as an biomarker to measure the presence of neuroinflammatory reactions. In this study, expression of TSPO was quantified via [F]DPA-714 positron emission tomography-magnetic resonance imaging (PET-MRI) imaging to investigate the effects of microglial activation associated with motor behavioral impairments in the 6-hydroxydopamine (6-OHDA)-treated rodent model of Parkinson's disease (PD). [F]FDG PET-MRI (for non-specific inflammation), [F]D-FP-(+)-DTBZ PET-MRI (for damaged dopaminergic neurons), post-PET immunofluorescence, and Pearson's correlation analyses were also performed. The time course of the striatal [F]DPA-714 binding ratio elevated in 6-OHDA-treated rats during 1-3 weeks post-treatment, with the peak TSPO binding in the 1st week. No differences between bilateral striatum in [F]FDG PET imaging were found. Moreover, an obvious correlation between [F]DPA-714 SUV and rotation numbers was found ( = 0.434, * = 0.049). No correlation between [F]FDG SUV and rotation behavior was found. [F]DPA-714 appeared to be a potential PET tracer for imaging the microglia-mediated neuroinflammation in the early stage of PD.
| Reference Key |
ye2023activatedacs
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| Authors | Ye, Peizhen;Bi, Lei;Yang, Min;Qiu, Yifan;Huang, Guolong;Liu, Yongshan;Hou, Yuyi;Li, Zhijun;Tong, Henry Hoi Yee;Cui, Mengchao;Jin, Hongjun; |
| Journal | ACS chemical neuroscience |
| Year | 2023 |
| DOI |
10.1021/acschemneuro.3c00080
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