Synthesis, characterization and cytotoxicity of copper (II) complex containing a 2H-benzo[e][1,3]oxazin derivative.

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2022
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Abstract
A new cis-dihalo copper(II) complex, [Cu(HL)(Cl)].CHCN (1), where HL = (S)-2-(((2-(2-(pyridin-2-yl)-2H-benzo[e][1,3]oxazin-3(4H)-yl)ethyl)amino)methyl)phenol), was isolated by reacting copper(II) chloride dihydrate and the HL ligand (HL = 2,2'-((2-(pyridin-2-yl)imidazolidine-1,3-diyl)bis(methylene))diphenol) in a MeOH/CHCN (1:3 v/v) mixture. The complex formation occurred via the ligand modification during complexation, producing a unique structure containing 2H-benzo[e][1,3]oxazin, as observed from the single crystal X-ray structure determination. The complex was characterized by elemental analysis, potentiometric titration, spectroscopic techniques (UV-Vis, FT-IR) and conductance measurements. Complex 1 inhibits the growth of myelogenous leukemia cells with an IC of 17.3 μmol L.
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Authors de Oliveira, José A F;Terra, Geovana G;Costa, Thiago G;Szpoganicz, Bruno;Silva-Caldeira, Priscila P;de Souza, Ívina P;Pereira-Maia, Elene C;Bortoluzzi, Adailton J;
Journal Journal of inorganic biochemistry
Year 2022
DOI
10.1016/j.jinorgbio.2022.112087
URL
Keywords
Cytotoxicity crystal structure biological activity benzoxazine ring cancer cells mononuclear copper(ii) complex

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