Generation of an induced pluripotent stem cell line FDHPIi001-A derived from a female patient with WDR45-related neurodegeneration disease carrying non-canonical splice site c.344 + 5G > T.

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ID: 275964
2022
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Abstract
The WDR45 encodes a beta-propeller scaffold protein which leads to β-propeller protein-associated neurodegeneration (BPAN) with iron accumulation in the brain. Using episomal reprogramming approach, we generated an iPSC line from peripheral blood mononuclear cells (PBMCs) from a 9-year-old girl with a non-canonical splice site c.344 + 5G > T in the WDR45 gene. The iPSC line had been fully examined about pluripotency marker, karyotype, and three germ layer differentiation.
Reference Key
xiang2022generationstem Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Xiang, Jingjing;Huang, Nana;Ouyang, Qianqian;Yi, Yuan;Ding, Yang;An, Yu;
Journal Stem cell research
Year 2022
DOI
10.1016/j.scr.2022.102992
URL
Keywords
Air pollution mortality pm(2.5) particle components secondary organic aerosols sulfate particles

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