Three-Component One-Pot Synthesis of Highly Functionalized Bis-Indole Derivatives.
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ID: 27584
2019
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Abstract
In this study, we detail the development of a concise and efficient three-component protocol for the regioselective synthesis of highly functionalized bis-indoles through a one-pot, two-step sequential process starting from enaminones , indoles , and acenaphthylene-1,2-dione that is catalyzed by piperidine and -methyl benzenesulfonic acid. This protocol has several advantages including simplicity of experimental operation, high efficiency of bond formation, ready availability and low cost of starting materials, environmentally benign conditions, and target molecular diversity.
| Reference Key |
chen2019threecomponentacs
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|---|---|
| Authors | Chen, Xue-Bing;Xiong, Sheng-Li;Xie, Zhi-Xu;Wang, Yong-Chao;Liu, Wei; |
| Journal | ACS omega |
| Year | 2019 |
| DOI |
10.1021/acsomega.9b01159
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| URL | |
| Keywords | Keywords not found |
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