Fusaroxazin, a novel cytotoxic and antimicrobial xanthone derivative from .

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ID: 275494
2022
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Abstract
Oxazines and their derivatives are an uncommon natural heterocyclic compounds, which contain oxygen and nitrogen atoms and possess various bioactivities. A novel 1,4-oxazine-xanthone derivative, fusarioxazin () and three known sterols () were separated from EtOAc extract associated with L. (broad bean, Fabaceae) roots. Their structural assignment was accomplished using various spectroscopic tools and comparing with literature data. The cytotoxic and antimicrobial potentials of the novel metabolite () were evaluated. It possessed a significant antibacterial activity towards . (IZD 14.8 mm and MIC 5.3 µg/mL) and (IZD 18.9 mm and MIC 3.7 µg/mL), in comparison to ciprofloxacin (IZDs 16.9 and 20.5 mm; MICs 3.9 and 2.3 µg/mL, respectively). Furthermore, it displayed a promising cytotoxic effect toward HCT-116 (IC 2.1 µM), MCF-7 (IC 1.8 µM), and A549 (IC 3.2 µM) comparable to doxorubicin (ICs 0.68, 0.54, and 0.39 µM, respectively).
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mohamed2022fusaroxazinnatural Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mohamed, Gamal Abdallah;Ibrahim, Sabrin Ragab Mohamed;Alhakamy, Nabil Abdulhafiz;Aljohani, Omar Saad;
Journal Natural product research
Year 2022
DOI
10.1080/14786419.2020.1855165
URL
Keywords
Antimicrobial endophytes cytotoxic fusarium oxysporum vicia faba

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