Glaucoma and Cornea Surgery Outcomes in Peters Anomaly.

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ID: 27529
2019
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Abstract
To conduct a qualitative description of corneal and glaucoma outcomes in Peters Anomaly.Retrospective case series METHODS: Children with Peters Anomaly, who presented between 1982-2017 were included. Visual acuity, intraocular pressure (IOP), survival of corneal grafts and success of glaucoma surgery (defined as IOP of 5-20 mmHg and no additional IOP-lowering surgery or visually devastating complications) were analyzed.Fifty-eight eyes of 37 patients (19 males) with Peters Anomaly presented at 0.7±1.5 years of age and had follow-up of 10.2±10.8 years. Twenty-three eyes underwent penetrating keratoplasty (PKP) with an average of 2.0±1.3 grafts/eye. PKP survival at 1-year was 60% [95% CI 41,75], but decreased at 10-years to 34% [95% CI 18,51]. Thirty-four eyes were diagnosed with glaucoma at 2.8±6.4 years of age. Twenty eyes required glaucoma surgery, and the average number of IOP-lowering surgeries was 2.9±2.0 per eye. Glaucoma drainage devices (GDD, 15 eyes) had a 53% success rate. Laser cycloablation (9 eyes, transcleral or endoscopic) had a success rate of 67% with 2.0±1.0 treatments/eye. Trabeculectomy with mitomycin-C (8 eyes) and trabeculotomy (8 eyes) had 25% and 0% success rates, respectively. Fifteen eyes that underwent glaucoma surgery obtained IOP control, and GDD ± cycloablation accounted for 80% of the successes. Eyes that underwent PKP did not show increased rates of glaucoma, higher IOP, or greater necessity for IOP-lowering surgery.In Peters Anomaly, PKP shows poor long-term success. Further, over half of eyes with Peters Anomaly have secondary glaucoma that often requires multiple surgeries.
Reference Key
dolezal2019glaucomaamerican Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dolezal, Kara A;Besirli, Cagri G;Mian, Shahzad I;Sugar, Alan;Moroi, Sayoko E;Bohnsack, Brenda L;
Journal American journal of ophthalmology
Year 2019
DOI
S0002-9394(19)30413-1
URL
Keywords Keywords not found

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