Serum endocan level and diastolic functions in the case of lead exposure

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ID: 274825
2019
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Abstract
Lead can cause morphological and functional changes in heart, and inflammation and endothelial dysfunction in vasculature. Endocan, as a novel indicator of endothelial dysfunction, has been used for cardiovascular diseases. This study investigated the relationship between lead exposure, endocan levels, and diastolic functions.A total of 51 lead-exposed workers without a known cardiovascular disease or risk factors and 54 healthy controls were enrolled. All participants underwent transthoracic echocardiography. Blood lead and serum endocan levels were analyzed.Baseline demographic and clinical characteristics were found to be similar between groups. Median blood lead (32 vs 1.5 μg/dL, P < 0.001) and serum endocan levels (67 vs 57.1 pg/mL, P = 0.02) were significantly higher in the lead-exposed group. Serum endocan level showed a positive correlation with blood lead levels (r = 0.404, P = 0.003) in lead-exposed workers. Serum endocan level was an independent risk factor for increased E/E’ ratio (β = 0.704, P = 0.002) and left atrial volume index (β = 1.158, P = 0.011) and higher level of lead in blood was an independent risk factor for increased E wave (β = 8.004, P = 0.022) in lead-exposed workers.Worsened diastolic functions may be seen in the course of lead exposure. Due to sharing a similar mechanism, a higher serum level of endocan may be a valuable laboratory clue for impaired diastolic function in this population.
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kara2019serumturkish Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kara, Halil;Karakulak, Uğur Nadir;Gündüzöz, Meside;Bal, Ceylan;Alışık, Murat;Büyükşekerci, Murat;İritaş, Servet Bilgin;Yılmaz, Ömer Hınç;Tutkun, Lütfiye;
Journal Turkish journal of medical sciences
Year 2019
DOI
10.3906/sag-1801-146
URL
Keywords
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