The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure

Clicks: 213
ID: 274376
2001
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Abstract
Some pathogens (e.g., Mycobacterium tuberculosis, Toxoplasma gondii, Leishmania spp) have been shown to persist in their host after clinical cure, establishing the risk of disease reactivation. We analyzed the conditions necessary for the long term maintenance of Leishmania major in genetically resi …
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Authors Belkaid Y;Hoffmann KF;Mendez S;Kamhawi S;Udey MC;Wynn TA;Sacks DL;;
Journal The Journal of experimental medicine
Year 2001
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11714756
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL animals pubmed abstract nih national institutes of health national library of medicine Antibodies Monoclonal / therapeutic use* Receptors Knockout cd8-positive t-lymphocytes / immunology cd4-positive t-lymphocytes / immunology skin / immunology leishmaniasis interferon-gamma / physiology interleukin-4 / physiology interleukin-10 / physiology* pmid:11714756 pmc2193677 doi:10.1084/jem.194.10.1497 y belkaid k f hoffmann d l sacks leishmania major / physiology* cutaneous / therapy* interleukin / antagonists & inhibitors* interleukin-10 skin / parasitology*

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