INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53
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ID: 273656
1999
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Abstract
The INK4a/ARF locus encodes upstream regulators of the retinoblastoma and p53 tumor suppressor gene products. To compare the impact of these loci on tumor development and treatment response, the Emu-myc transgenic lymphoma model was used to generate genetically defined tumors with mutations in the I …
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| Reference Key |
ca1999genesink4a/arf
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|---|---|
| Authors | Schmitt CA;McCurrach ME;de Stanchina E;Wallace-Brodeur RR;Lowe SW;; |
| Journal | genes & development |
| Year | 1999 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
genetic
Mice
Inbred C57BL
animals
humans
pubmed abstract
nih
national institutes of health
national library of medicine
research support
non-u.s. gov't
u.s. gov't
female
male
P.H.S.
Genes
enhancer elements
Knockout
lymphoma
proteins / genetics*
transgenic
mutation*
apoptosis / genetics
antineoplastic agents / pharmacology
p53*
Tumor Suppressor Protein p14ARF
myc
p16*
b-cell / etiology*
b-cell / genetics*
c a schmitt
s w lowe
immunoglobulin heavy chains / genetics
pmid:10541553
pmc317110
doi:10.1101/gad.13.20.2670
m e mccurrach
drug resistance / genetics
b-cell / drug therapy
|
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