INK4a/ARF mutations accelerate lymphomagenesis and promote chemoresistance by disabling p53

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ID: 273656
1999
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Abstract
The INK4a/ARF locus encodes upstream regulators of the retinoblastoma and p53 tumor suppressor gene products. To compare the impact of these loci on tumor development and treatment response, the Emu-myc transgenic lymphoma model was used to generate genetically defined tumors with mutations in the I …
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ca1999genesink4a/arf Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Schmitt CA;McCurrach ME;de Stanchina E;Wallace-Brodeur RR;Lowe SW;;
Journal genes & development
Year 1999
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10541553
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice Inbred C57BL animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't female male P.H.S. Genes enhancer elements Knockout lymphoma proteins / genetics* transgenic mutation* apoptosis / genetics antineoplastic agents / pharmacology p53* Tumor Suppressor Protein p14ARF myc p16* b-cell / etiology* b-cell / genetics* c a schmitt s w lowe immunoglobulin heavy chains / genetics pmid:10541553 pmc317110 doi:10.1101/gad.13.20.2670 m e mccurrach drug resistance / genetics b-cell / drug therapy

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