Sofosbuvir for previously untreated chronic hepatitis C infection

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ID: 273565
2013
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Abstract
In a single-group study of sofosbuvir combined with peginterferon-ribavirin, patients with predominantly genotype 1 or 4 HCV infection had a rate of sustained virologic response of 90% at 12 weeks. In a noninferiority trial, patients with genotype 2 or 3 infection who received either sofosbuvir or p …
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Authors Lawitz E;Mangia A;Wyles D;Rodriguez-Torres M;Hassanein T;Gordon SC;Schultz M;Davis MN;Kayali Z;Reddy KR;Jacobson IM;Kowdley KV;Nyberg L;Subramanian GM;Hyland RH;Arterburn S;Jiang D;McNally J;Brainard D;Symonds WT;McHutchison JG;Sheikh AM;Younossi Z;Gane EJ;;
Journal The New England journal of medicine
Year 2013
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/23607594
Keywords
hepatitis c National Center for Biotechnology Information NCBI NLM MEDLINE RNA humans pubmed abstract nih national institutes of health national library of medicine logistic models research support non-u.s. gov't adult female male aged middle aged young adult Clinical Trial Phase III Randomized Controlled Trial Multicenter Study Genotype viral / blood drug therapy combination antiviral agents / therapeutic use* ribavirin / therapeutic use* recombinant proteins / adverse effects recombinant proteins / therapeutic use chronic / virology antiviral agents / adverse effects hepacivirus / genetics* chronic / drug therapy* interferon-alpha / adverse effects interferon-alpha / therapeutic use* polyethylene glycols / adverse effects polyethylene glycols / therapeutic use* ribavirin / adverse effects eric lawitz alessandra mangia liver cirrhosis / virology sofosbuvir uridine monophosphate / analogs & derivatives* uridine monophosphate / therapeutic use pmid:23607594 doi:10.1056/nejmoa1214853 edward j gane uridine monophosphate / adverse effects

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