Roles for Nkx3.1 in prostate development and cancer

Clicks: 231
ID: 273497
1999
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Abstract
In aging men, the prostate gland becomes hyperproliferative and displays a propensity toward carcinoma. Although this hyperproliferative process has been proposed to represent an inappropriate reactivation of an embryonic differentiation program, the regulatory genes responsible for normal prostate …
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Authors Bhatia-Gaur R;Donjacour AA;Sciavolino PJ;Kim M;Desai N;Young P;Norton CR;Gridley T;Cardiff RD;Cunha GR;Abate-Shen C;Shen MM;;
Journal genes & development
Year 1999
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10215624
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice gene expression animals humans pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't non-p.h.s. male P.H.S. Genes cell differentiation epithelium transcription factors / physiology* transcription factors / genetics proteins / metabolism gene targeting prostatic neoplasms / pathology prostate / metabolism prostatic neoplasms / genetics prostate / pathology prostatic hyperplasia / pathology morphogenesis tumor suppressor* homeodomain proteins / genetics pmid:10215624 pmc316645 doi:10.1101/gad.13.8.966 r bhatia-gaur a a donjacour m m shen bulbourethral glands / metabolism homeodomain proteins / physiology* prostate / embryology prostatic hyperplasia / etiology* prostatic hyperplasia / genetics prostatic neoplasms / etiology*

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