Phenotype of mice and macrophages deficient in both phagocyte oxidase and inducible nitric oxide synthase

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ID: 273258
1999
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Abstract
The two genetically established antimicrobial mechanisms of macrophages are production of reactive oxygen intermediates by phagocyte oxidase (phox) and reactive nitrogen intermediates by inducible nitric oxide synthase (NOS2). Mice doubly deficient in both enzymes (gp91(phox-/-)/NOS2(-/-)) formed ma …
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Authors Shiloh MU;MacMicking JD;Nicholson S;Brause JE;Potter S;Marino M;Fang F;Dinauer M;Nathan C;;
Journal immunity
Year 1999
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10023768
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice Inbred C57BL animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't P.H.S. phenotype Crosses Knockout macrophages escherichia coli / immunology genetic predisposition to disease bacterial infections / immunology inbred strains membrane glycoproteins / genetics animal / immunology nitric oxide synthase / genetics nitric oxide synthase type ii salmonella infections listeria monocytogenes / immunology nadph oxidases / genetics pmid:10023768 doi:10.1016/s1074-7613(00)80004-7 m u shiloh j d macmicking c nathan abscess / genetics abscess / immunology bacterial infections / genetics listeriosis / genetics listeriosis / immunology peritoneal / enzymology* peritoneal / immunology* peritoneal / microbiology membrane glycoproteins / deficiency* nadph oxidase 2 nadph oxidases / deficiency* nitric oxide synthase / deficiency* animal / genetics salmonella typhimurium / immunology

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