Mechanism of action of T-705 against influenza virus

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ID: 273113
2005
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Abstract
T-705, a substituted pyrazine compound, has been found to exhibit potent anti-influenza virus activity in vitro and in vivo. In a time-of-addition study, it was indicated that T-705 targeted an early to middle stage of the viral replication cycle but had no effect on the adsorption or release stage. …
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Authors Furuta Y;Takahashi K;Kuno-Maekawa M;Sangawa H;Uehara S;Kozaki K;Nomura N;Egawa H;Shiraki K;;
Journal Antimicrobial agents and chemotherapy
Year 2005
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/15728892
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine chromatography antiviral agents / pharmacology* rna / biosynthesis high pressure liquid orthomyxoviridae / drug effects* yousuke furuta amides / pharmacology* pyrazines / pharmacology* pmid:15728892 pmc549233 doi:10.1128/aac.49.3.981-986.2005 kazumi takahashi kimiyasu shiraki dna / biosynthesis dna-directed rna polymerases / antagonists & inhibitors imp dehydrogenase / antagonists & inhibitors

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