Predictors of insufficient amikacin peak concentration in critically ill patients receiving a 25 mg/kg total body weight regimen

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ID: 272824
2014
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Abstract
Despite an amikacin dose of 25 mg/kg of total body weight, 33% of patients still had an amikacin Cmax < 60 mg/L. Positive 24-h fluid balance was identified as a predictive factor of Cmax < 60 mg/L. When total body weight is used, low BMI tended to be associated with amikacin underdosing. These …
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Authors de Montmollin E;Bouadma L;Gault N;Mourvillier B;Mariotte E;Chemam S;Massias L;Papy E;Tubach F;Wolff M;Sonneville R;;
Journal intensive care medicine
Year 2014
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/24687298
Keywords
injections National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine female male aged middle aged Prospective Studies risk factors body mass index multivariate analysis observational study anti-bacterial agents / administration & dosage* dose-response relationship drug intensive care units critical illness intravenous body weight* infusions gram-negative bacterial infections / drug therapy amikacin / administration & dosage* pmid:24687298 doi:10.1007/s00134-014-3276-x etienne de montmollin lila bouadma romain sonneville amikacin / blood* anti-bacterial agents / blood*

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