The role of sonic hedgehog-Gli2 pathway in the masculinization of external genitalia

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ID: 272489
2011
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Abstract
During embryogenesis, sexually dimorphic organogenesis is achieved by hormones produced in the gonad. The external genitalia develop from a single primordium, the genital tubercle, and their masculinization processes depend on the androgen signaling. In addition to such hormonal signaling, the invol …
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Authors Miyagawa S;Matsumaru D;Murashima A;Omori A;Satoh Y;Haraguchi R;Motoyama J;Iguchi T;Nakagata N;Hui CC;Yamada G;;
Journal endocrinology
Year 2011
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/21586556
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female male N.I.H. Extramural signal transduction* Knockout transgenic epithelium / metabolism male / metabolism genitalia gene silencing androgens / pharmacology epithelium / embryology male / embryology* mesoderm / metabolism pmid:21586556 pmc3115609 doi:10.1210/en.2011-0263 shinichi miyagawa daisuke matsumaru gen yamada epithelium / drug effects female / drug effects female / embryology female / metabolism male / drug effects hedgehog proteins / genetics hedgehog proteins / metabolism* hypospadias / chemically induced hypospadias / embryology hypospadias / metabolism kruppel-like transcription factors / genetics kruppel-like transcription factors / metabolism* mesoderm / drug effects mutant proteins / genetics mutant proteins / metabolism sex determination processes* testosterone propionate / pharmacology urethra / drug effects urethra / embryology urethra / metabolism zinc finger protein gli2

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