In vitro and in vivo activities of anti-influenza virus compound T-705

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ID: 272486
2002
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Abstract
T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) has been found to have potent and selective inhibitory activity against influenza virus. In an in vitro plaque reduction assay, T-705 showed potent inhibitory activity against influenza A, B, and C viruses, with 50% inhibitory concentrations (IC(50)s) …
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Authors Furuta Y;Takahashi K;Fukuda Y;Kuno M;Kamiyama T;Kozaki K;Nomura N;Egawa H;Minami S;Watanabe Y;Narita H;Shiraki K;;
Journal Antimicrobial agents and chemotherapy
Year 2002
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11897578
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine male cell line Inbred BALB C microbial sensitivity tests antiviral agents / therapeutic use* antiviral agents / pharmacology* influenza human / drug therapy* lung / virology human / virology drug screening assays antitumor k takahashi orthomyxoviridae / drug effects* amides / therapeutic use* pyrazines / therapeutic use* pmid:11897578 pmc127093 doi:10.1128/aac.46.4.977-981.2002 y furuta k shiraki amides / pharmacology* pyrazines / pharmacology* viruses / drug effects

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