Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene

Clicks: 259
ID: 272480
1998
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Abstract
Neuropeptide Y (NPY), a peptide synthesized in the hypothalamic arcuate nucleus, is implicated in the physiologic control of food intake and body weight. Because both genetic (e.g. in obese ob/ob mice) and acquired leptin deficiency (e.g. fasting in normal mice) increase hypothalamic NPY accumulatio …
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Authors Schwartz MW;Erickson JC;Baskin DG;Palmiter RD;;
Journal endocrinology
Year 1998
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9564880
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice gene expression animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't non-p.h.s. P.H.S. mutation Knockout transcription kinetics proteins / genetics hypothalamus / metabolism* leptin proteins / physiology* obese fasting* arcuate nucleus of hypothalamus / metabolism pmid:9564880 doi:10.1210/endo.139.5.6000 m w schwartz j c erickson r d palmiter neuropeptide y / genetics* proteins / pharmacology beta-galactosidase / genetics*

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