Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair
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ID: 272277
2020
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Abstract
Defects in DNA single-strand break repair are associated with neurodegenerative disease. Here the authors reveal that mutations in ARH3 interfere with the catabolism of mono-(ADP-ribose) and lead to its accumulation on core histones following repair of endogenous or exogenous DNA single-strand breaks.
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hanzlikova2020pathogenicnature
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| Authors | Hanzlikova, Hana;Prokhorova, Evgeniia;Krejcikova, Katerina;Cihlarova, Zuzana;Kalasova, Ilona;Kubovciak, Jan;Sachova, Jana;Hailstone, Richard;Brazina, Jan;Ghosh, Shereen;Cirak, Sebahattin;Gleeson, Joseph G.;Ahel, Ivan;Caldecott, Keith W.; |
| Journal | Nature communications |
| Year | 2020 |
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