Pathogenic ARH3 mutations result in ADP-ribose chromatin scars during DNA strand break repair

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ID: 272277
2020
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Abstract
Defects in DNA single-strand break repair are associated with neurodegenerative disease. Here the authors reveal that mutations in ARH3 interfere with the catabolism of mono-(ADP-ribose) and lead to its accumulation on core histones following repair of endogenous or exogenous DNA single-strand breaks.
Reference Key
hanzlikova2020pathogenicnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hana Hanzlikova, Evgeniia Prokhorova, Katerina Krejcikova, Zuzana Cihlarova, Ilona Kalasova, Jan Kubovciak, Jana Sachova, Richard Hailstone, Jan Brazina, Shereen Ghosh, Sebahattin Cirak, Joseph G. Gleeson, Ivan Ahel, Keith W. Caldecott
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Journal Nature communications
Year 2020
DOI
DOI not found
URL
https://doi.org/10.1038/s41467-020-17069-9
Keywords
Zoology Microbiology Botany Engineering (General). Civil engineering (General) Science general. including nature conservation, geographical distribution geology

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