Potent and long-acting dimeric inhibitors of influenza virus neuraminidase are effective at a once-weekly dosing regimen

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ID: 271839
2004
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Abstract
Dimeric derivatives (compounds 7 to 9) of the influenza virus neuraminidase inhibitor zanamivir (compound 2), which have linking groups of 14 to 18 atoms in length, are approximately 100-fold more potent inhibitors of influenza virus replication in vitro and in vivo than zanamivir. The observed opti …
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Authors Macdonald SJ;Watson KG;Cameron R;Chalmers DK;Demaine DA;Fenton RJ;Gower D;Hamblin JN;Hamilton S;Hart GJ;Inglis GG;Jin B;Jones HT;McConnell DB;Mason AM;Nguyen V;Owens IJ;Parry N;Reece PA;Shanahan SE;Smith D;Wu WY;Tucker SP;;
Journal Antimicrobial agents and chemotherapy
Year 2004
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/15561823
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice gel animals pubmed abstract nih national institutes of health national library of medicine male Rats Sprague-Dawley cell line microscopy kinetics electron enzyme inhibitors / pharmacology* orthomyxoviridae infections / prevention & control chromatography dogs antiviral agents / pharmacology* indicators and reagents antiviral agents / therapeutic use lung / metabolism cytopathogenic effect viral / drug effects virus replication / drug effects antiviral agents / administration & dosage* structure-activity relationship viral plaque assay enzyme inhibitors / administration & dosage* guanidines neuraminidase / antagonists & inhibitors* pyrans zanamivir sialic acids / pharmacology orthomyxoviridae / drug effects pmid:15561823 pmc529190 doi:10.1128/aac.48.12.4542-4549.2004 simon j f macdonald keith g watson simon p tucker enzyme inhibitors / therapeutic use orthomyxoviridae / enzymology* orthomyxoviridae / growth & development sialic acids / chemistry

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