Association between altered expression of adipogenic factor SREBP1 in lipoatrophic adipose tissue from HIV-1-infected patients and abnormal adipocyte differentiation and insulin resistance

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ID: 271745
2002
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Abstract
The altered differentiation status of peripheral adipocytes in HIV-1-infected patients with antiretroviral-induced lipoatrophy is associated with greatly reduced SREBP1c expression. Since the differentiation factor SREBP1 is rapidly targeted by protease inhibitors in vitro, our results suggest that …
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Authors Bastard JP;Caron M;Vidal H;Jan V;Auclair M;Vigouroux C;Luboinski J;Laville M;Maachi M;Girard PM;Rozenbaum W;Levan P;Capeau J;;
Journal Lancet (London, England)
Year 2002
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11937183
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE RNA humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't adult female male middle aged Comparative Study Insulin Resistance* Receptors Adipose Tissue / metabolism* hiv infections / complications* hiv-1* cell differentiation messenger / analysis hiv infections / drug therapy* dna-binding proteins / genetics adipocytes / pathology* hiv infections / pathology* sterol regulatory element binding protein 1 ccaat-enhancer-binding proteins / genetics tumor necrosis factor-alpha / analysis dna-binding proteins / analysis* transcription factors / analysis pmid:11937183 doi:10.1016/s0140-6736(02)08094-7 jean philippe bastard martine caron jacqueline capeau ccaat-enhancer-binding protein-alpha / analysis ccaat-enhancer-binding protein-beta / analysis ccaat-enhancer-binding proteins / analysis* leptin / analysis lipodystrophy / metabolism* lipodystrophy / pathology* protease inhibitors / adverse effects* cytoplasmic and nuclear / analysis

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