Mice lacking ghrelin receptors resist the development of diet-induced obesity

تقاوم الفئران التي تفتقر إلى مستقبلات الغريلين تطور السمنة المستحثة بالنظام الغذائي

Clicks: 532
ID: 271400
2005
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Abstract
Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor (GHSR; ghrelin receptor). Since its discovery, accumulating evidence has suggested that ghrelin may play a role in signaling and reversing states of energy insufficiency. For example, ghrelin levels rise following food dep …
يُعدّ الغريلين الرّبيطة داخلية المنشأ لمستقبل مفرزات هرمون النمو (GHSR؛ مستقبل الغريلين). ومنذ اكتشافه، أشارت الأدلة المتراكمة إلى أن الغريلين قد يؤدي دورًا في الإشارة إلى حالات عوز الطاقة وعكسها. فعلى سبيل المثال، ترتفع مستويات الغريلين عقب الحرمان من الطعـ...
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jm2005themice Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zigman JM;Nakano Y;Coppari R;Balthasar N;Marcus JN;Lee CE;Jones JE;Deysher AE;Waxman AR;White RD;Williams TD;Lachey JL;Seeley RJ;Lowell BB;Elmquist JK;;
Journal The Journal of clinical investigation
Year 2005
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/16322794
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice Inbred C57BL RNA animals pubmed abstract nih national institutes of health national library of medicine models research support non-u.s. gov't female male N.I.H. Extramural Obesity / metabolism phenotype recombination Body Weight Receptors Genotype Blood Glucose / metabolism Crosses time factors messenger / metabolism adipose tissue / metabolism analysis of variance neurons / metabolism blotting western signal transduction diet* southern genetic predisposition to disease silver staining homeostasis leptin / metabolism insulin-like growth factor i / metabolism dna / metabolism body composition obesity / genetics* gene deletion magnetic resonance spectroscopy recombinant proteins / genetics alleles recombinant proteins / metabolism heterozygote joel k elmquist animal feed ghrelin pmid:16322794 pmc1297251 doi:10.1172/jci26002 jeffrey m zigman yoshihide nakano hyperglycemia / metabolism peptide hormones / chemistry peptide hormones / physiology* g-protein-coupled / genetics* g-protein-coupled / physiology*

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