Neuropathological assessment of artemether-treated severe malaria

Clicks: 211
ID: 271340
2003
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Abstract
In animals, high doses of intramuscular artemether and artemotil have been shown to cause an unusual pattern of selective damage to certain brainstem nuclei, especially those implicated in hearing and balance. We aimed to investigate whether a similar pattern arises in human adults. We examined the …
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Authors Hien TT;Turner GD;Mai NT;Phu NH;Bethell D;Blakemore WF;Cavanagh JB;Dayan A;Medana I;Weller RO;Day NP;White NJ;;
Journal Lancet (London, England)
Year 2003
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/12892962
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't adult female male Comparative Study malaria antimalarials / therapeutic use quinine / therapeutic use falciparum / pathology falciparum / drug therapy* antimalarials / adverse effects* artemether sesquiterpenes / adverse effects* sesquiterpenes / therapeutic use pmid:12892962 doi:10.1016/s0140-6736(03)13974-8 t t hien g d h turner n j white artemisinins / adverse effects* artemisinins / therapeutic use brain diseases / chemically induced* brain diseases / pathology* brain stem / drug effects brain stem / pathology quinine / adverse effects

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