Efficacy of orally administered T-705 on lethal avian influenza A (H5N1) virus infections in mice

Clicks: 324
ID: 270849
2007
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Abstract
T-705 (6-fluoro-3-hydroxy-2-pyrazinecarboxamide) was inhibitory to four strains of avian H5N1 influenza virus in MDCK cells, with the 90% effective concentrations ranging from 1.3 to 7.7 microM, as determined by a virus yield reduction assay. The efficacy was less than that exerted by oseltamivir ca …
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Authors Sidwell RW;Barnard DL;Day CW;Smee DF;Bailey KW;Wong MH;Morrey JD;Furuta Y;;
Journal Antimicrobial agents and chemotherapy
Year 2007
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/17194832
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine research support N.I.H. Extramural Comparative Study Cells Cultured Inbred BALB C Viral Survival Analysis lung / pathology antiviral agents / administration & dosage antiviral agents / therapeutic use* influenza human / drug therapy* cytopathogenic effect virus replication / drug effects oxygen / blood influenza a virus lung / virology human / virology oseltamivir / therapeutic use human / pathology pmid:17194832 pmc1803113 doi:10.1128/aac.01051-06 robert w sidwell dale l barnard yousuke furuta amides / administration & dosage amides / therapeutic use* h5n1 subtype* pyrazines / administration & dosage pyrazines / therapeutic use*

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