The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis

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ID: 270402
2003
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Abstract
The gastrointestinal peptide hormone ghrelin stimulates appetite in rodents and humans via hypothalamic actions. We discovered expression of ghrelin in a previously uncharacterized group of neurons adjacent to the third ventricle between the dorsal, ventral, paraventricular, and arcuate hypothalamic …
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Authors Cowley MA;Smith RG;Diano S;Tschöp M;Pronchuk N;Grove KL;Strasburger CJ;Bidlingmaier M;Esterman M;Heiman ML;Garcia-Segura LM;Nillni EA;Mendez P;Low MJ;Sotonyi P;Friedman JM;Liu H;Pinto S;Colmers WF;Cone RD;Horvath TL;;
Journal neuron
Year 2003
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/12597862
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't female protein biosynthesis P.H.S. Rats Knockout Organ Specificity in vitro techniques transgenic neurons / metabolism hypothalamus / metabolism* paraventricular hypothalamic nucleus / drug effects agouti-related protein ghrelin hypothalamus / drug effects intercellular signaling peptides and proteins luminescent proteins / biosynthesis neurons / cytology pmid:12597862 doi:10.1016/s0896-6273(03)00063-1 michael a cowley roy g smith tamas l horvath central nervous system / cytology central nervous system / metabolism* corticotropin-releasing hormone / biosynthesis energy metabolism / physiology* homeostasis / physiology* hypothalamus / cytology nerve net / metabolism* neuropeptide y / biosynthesis paraventricular hypothalamic nucleus / metabolism patch-clamp techniques peptide hormones / metabolism* peptide hormones / pharmacology presynaptic terminals / metabolism pro-opiomelanocortin / biosynthesis protein binding / physiology proteins*

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