Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation

Clicks: 295
ID: 269560
2008
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Abstract
Bone morphogenetic proteins (BMPs) play important roles in regulating lung development and function although the endogenous regulatory effects of BMP signaling are still controversial. We found that BMP type I receptor Alk3 is expressed predominantly in airway epithelial cells during development. Th …
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Authors Sun J;Chen H;Chen C;Whitsett JA;Mishina Y;Bringas P;Ma JC;Warburton D;Shi W;;
Journal the american journal of pathology
Year 2008
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/18258849
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice Inbred C57BL gene expression regulation animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't female N.I.H. Extramural newborn Knockout Organ Specificity developmental transgenic signal transduction lung / metabolism bone morphogenetic protein receptors lung / embryology pmid:18258849 pmc2258256 doi:10.2353/ajpath.2008.070286 jianping sun hui chen wei shi type i / genetics* type i / metabolism bone morphogenetic proteins / metabolism* lung / abnormalities* organogenesis / genetics respiratory insufficiency / embryology respiratory insufficiency / metabolism* respiratory mucosa / embryology respiratory mucosa / metabolism*

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