Western Diet Induced Remodelling of the Tongue Proteome

Clicks: 210
ID: 269423
2021
Free PDF
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
The tongue is a heavily innervated and vascularized striated muscle that plays an important role in vocalization, swallowing and digestion. The surface of the tongue is lined with papillae which contain gustatory cells expressing various taste receptors. There is growing evidence to suggest that our perceptions of taste and food preference are remodelled following chronic consumption of Western diets rich in carbohydrate and fats. Our sensitivity to taste and also to metabolising Western diets may be a key factor in the rising prevalence of obesity; however, a systems-wide analysis of the tongue is lacking. Here, we defined the proteomic landscape of the mouse tongue and quantified changes following chronic consumption of a chow or Western diet enriched in lipid, fructose and cholesterol for 7 months. We observed a dramatic remodelling of the tongue proteome including proteins that regulate fatty acid and mitochondrial metabolism. Furthermore, the expressions of several receptors, metabolic enzymes and hormones were differentially regulated, and are likely to provide novel therapeutic targets to alter taste perception and food preference to combat obesity.
Reference Key
dutt2021proteomeswestern Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Mriga Dutt;Yaan-Kit Ng;Jeffrey Molendijk;Hamzeh Karimkhanloo;Luoping Liao;Ronnie Blazev;Magdalene K. Montgomery;Matthew J. Watt;Benjamin L. Parker;Dutt, Mriga;Ng, Yaan-Kit;Molendijk, Jeffrey;Karimkhanloo, Hamzeh;Liao, Luoping;Blazev, Ronnie;Montgomery, Magdalene K.;Watt, Matthew J.;Parker, Benjamin L.;
Journal proteomes
Year 2021
DOI
10.3390/proteomes9020022
URL
https://www.mdpi.com/2227-7382/9/2/22
Keywords
Proteomics obesity metabolism taste high-fat diet tongue

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.