Intranasal granulocyte-macrophage colony-stimulating factor reduces the Aspergillus burden in an immunosuppressed murine model of pulmonary aspergillosis

عامل تحفيز مستعمرات المحببات والبلاعم داخل الأنف يقلل من عبء الرشاشيات في نموذج فأري مُثبَّط المناعة لداء الرشاشيات الرئوي

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ID: 269202
2008
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Abstract
We demonstrated that intranasal granulocyte-macrophage colony-stimulating factor given to immunosuppressed mice infected with pulmonary aspergillosis resulted in a sixfold reduction in the lung fungal burden compared to the result for saline-treated mice (P = 0.045). These data suggest that lung-tar …
أثبتنا أن إعطاء عامل تحفيز مستعمرات الخلايا المحببة والبلعمية عبر الأنف لفئران مثبطة مناعيًا ومصابة بداء الرشاشيات الرئوي قد أدى إلى انخفاض العبء الفطري في الرئة بمقدار ستة أضعاف، مقارنةً بالنتيجة لدى الفئران المعالجة بالمحلول الملحي (P = 0.045). وتشير هذه البيانات إلى أن استهداف الرئـ …
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g2008antimicrobialintranasal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Quezada G, Koshkina NV, Zweidler-McKay P, Zhou Z, Kontoyiannis DP, Kleinerman ES
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Journal Antimicrobial agents and chemotherapy
Year 2008
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/17984233
Keywords
Administration National Center for Biotechnology Information NCBI NLM MEDLINE Mice animals humans pubmed abstract nih national institutes of health national library of medicine treatment outcome research support non-u.s. gov't female Disease Models animal* cyclophosphamide / administration & dosage intranasal immunocompromised host* aspergillosis / microbiology lung diseases immunosuppressive agents / administration & dosage aspergillosis / drug therapy* pmid:17984233 pmc2224773 doi:10.1128/aac.00760-07 gerardo quezada nadezhda v koshkina eugenie s kleinerman aspergillus fumigatus / drug effects* granulocyte-macrophage colony-stimulating factor / administration & dosage* fungal* / drug therapy fungal* / microbiology

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