Efficacy of Glecaprevir/Pibrentasvir for 8 or 12 Weeks in Patients With Hepatitis C Virus Genotype 2, 4, 5, or 6 Infection Without Cirrhosis

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ID: 269154
2018
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Abstract
In 3 Phase 3 studies, 8 weeks' treatment with glecaprevir/pibrentasivr produced an SVR12 in at least 93% of patients with chronic HCV genotype 2, 4, 5, or 6 infection without cirrhosis, with virologic failure in less than 1%. The drug combination had a safety profile comparable to 12 week's treatmen …
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Authors Asselah T;Kowdley KV;Zadeikis N;Wang S;Hassanein T;Horsmans Y;Colombo M;Calinas F;Aguilar H;de Ledinghen V;Mantry PS;Hezode C;Marinho RT;Agarwal K;Nevens F;Elkhashab M;Kort J;Liu R;Ng TI;Krishnan P;Lin CW;Mensa FJ;;
Journal clinical gastroenterology and hepatology : the official clinical practice journal of the american gastroenterological association
Year 2018
DOI
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URL
http://www.ncbi.nlm.nih.gov/pubmed/28951228
Keywords
hepatitis c National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine treatment outcome adult female male aged middle aged Clinical Trial Phase III Randomized Controlled Trial Double-Blind Method Multicenter Study Genotype antiviral agents / therapeutic use* chronic / virology antiviral agents / adverse effects placebos / administration & dosage chronic / drug therapy* hepacivirus / classification hepacivirus / genetics Quinoxalines / adverse effects Quinoxalines / therapeutic use* sulfonamides / therapeutic use* federico j mensa benzimidazoles / adverse effects sulfonamides / adverse effects pmid:28951228 doi:10.1016/j.cgh.2017.09.027 tarik asselah kris v kowdley benzimidazoles / therapeutic use* drug-related side effects and adverse reactions / epidemiology drug-related side effects and adverse reactions / pathology

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