Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis

Clicks: 304
ID: 269096
1999
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Abstract
Transgenic mice expressing the c-Myc oncogene driven by the immunoglobulin heavy chain enhancer (Emu) develop B-cell lymphoma and exhibit a mean survival time of approximately 6 months. The protracted latent period before the onset of frank disease likely reflects the ability of c-Myc to induce a p5 …
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Authors Eischen CM;Weber JD;Roussel MF;Sherr CJ;Cleveland JL;;
Journal genes & development
Year 1999
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/10541552
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice Inbred C57BL animals pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't female male P.H.S. Cells Cultured Genes enhancer elements mutation Knockout lymphoma proteins / genetics* hematopoietic stem cells / cytology transgenic apoptosis / genetics proto-oncogene proteins / genetics* nuclear proteins* C M Eischen myc* p53* Tumor Suppressor Protein p14ARF proto-oncogene proteins c-mdm2 b-cell / etiology* b-cell / genetics* b-cell / pathology pmid:10541552 pmc317106 doi:10.1101/gad.13.20.2658 j d weber j l cleveland b-lymphocytes / cytology immunoglobulin heavy chains / genetics

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