Dynamic Hyperglycemic Patterns Predict Adverse Outcomes in Patients with Acute Ischemic Stroke Undergoing Mechanical Thrombectomy

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ID: 268625
2020
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Abstract
Background: Admission hyperglycemia impairs outcome in acute ischemic stroke (AIS) patients undergoing mechanical thrombectomy (MT). Since hyperglycemia in AIS represents a dynamic condition, we tested whether the dynamic patterns of hyperglycemia, defined as blood glucose levels > 140 mg/dl, affect outcomes in these patients. Methods: We retrospectively analyzed data of 200 consecutive patients with prospective follow-up. Based on blood glucose level, patients were distinguished into 4 groups: (1) persistent normoglycemia; (2) hyperglycemia at baseline only; (3) hyperglycemia at 24-h only; and (4) persistent (at baseline plus at 24-h following MT) hyperglycemia. Results: AIS patients with persistent hyperglycemia have a significantly increased risk of poor functional outcome (OR 6.89, 95% CI 1.98–23.94, p = 0.002, for three-month poor outcome; OR 11.15, 95% CI 2.99–41.52, p = 0.001, for no major neurological improvement), mortality (OR 5.37, 95% CI 1.61–17.96, p = 0.006, for in-hospital mortality; OR 4.43, 95% CI 1.40–13.97, p = 0.01, for three-month mortality), and hemorrhagic transformation (OR 6.89, 95% CI 2.35–20.21, p = 0.001, for intracranial hemorrhage; OR 5.42, 95% CI 1.54–19.15, p = 0.009, for symptomatic intracranial hemorrhage) after endovascular treatment. These detrimental effects were partially confirmed after also excluding diabetic patients. The AUC-ROC showed a very good performance for predicting three-month poor outcome (0.76) in-hospital mortality (0.79) and three-month mortality (0.79). Conclusions: Our study suggests that it is useful to perform the prolonged monitoring of glucose levels lasting 24-h after MT.
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merlino2020journaldynamic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Giovanni Merlino, Carmelo Smeralda, Massimo Sponza, Gian Luigi Gigli, Simone Lorenzut, Alessandro Marini, Andrea Surcinelli, Sara Pez, Alessandro Vit, Vladimir Gavrilovic, Mariarosaria Valente, Giovanni Merlino, Carmelo Smeralda, Massimo Sponza, Gian Luigi Gigli, Simone Lorenzut, Alessandro Marini, Andrea Surcinelli, Sara Pez, Alessandro Vit, Vladimir Gavrilovic, Mariarosaria Valente
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Journal journal of clinical medicine
Year 2020
DOI
10.3390/jcm9061932
URL
https://www.mdpi.com/2077-0383/9/6/1932
Keywords
hyperglycemia mechanical thrombectomy acute ischemic stroke large vessel occlusion

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