Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis

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ID: 268623
2008
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Abstract
Transforming growth factor (TGF)-beta is an important paracrine factor in tumorigenesis. Ligand binding of the type I and II TGF-beta receptors initiate downstream signaling. The role of stromal TGF-beta signaling in prostate cancer progression is unknown. In mice, the conditional stromal knockout o …
Reference Key
x2008oncogeneprostate Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Li X;Placencio V;Iturregui JM;Uwamariya C;Sharif-Afshar AR;Koyama T;Hayward SW;Bhowmick NA;;
Journal Oncogene
Year 2008
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18724388
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE Mice gene expression regulation animals humans pubmed abstract nih national institutes of health national library of medicine models research support u.s. gov't non-p.h.s. male N.I.H. Extramural neoplastic* Receptors ligands Knockout biological disease progression signal transduction scid receptor transforming growth factor beta / metabolism* transforming growth factor beta / metabolism wnt proteins / metabolism* prostatic neoplasms / metabolism* protein-serine-threonine kinases / metabolism neoplasm transplantation pmid:18724388 pmc3222150 doi:10.1038/onc.2008.293 x li v placencio n a bhowmick adenocarcinoma / metabolism paracrine communication transforming growth factor-beta type ii wnt3 protein wnt3a protein

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