Computational prediction of essential genes in an unculturable endosymbiotic bacterium, Wolbachia of Brugia malayi

Clicks: 317
ID: 268454
2009
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Abstract
Wolbachia (wBm) is an obligate endosymbiotic bacterium of Brugia malayi, a parasitic filarial nematode of humans and one of the causative agents of lymphatic filariasis. There is a pressing need for new drugs against filarial parasites, such as B. malayi. As wBm is required for B. malayi development and fertility, targeting wBm is a promising approach. However, the lifecycle of neither B. malayi nor wBm can be maintained in vitro. To facilitate selection of potential drug targets we computationally ranked the wBm genome based on confidence that a particular gene is essential for the survival of the bacterium.
Reference Key
kumar2009bmccomputational Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alexander G Holman,Paul J Davis,Jeremy M Foster,Clotilde K S Carlow,Sanjay Kumar;Alexander G Holman;Paul J Davis;Jeremy M Foster;Clotilde K S Carlow;Sanjay Kumar;
Journal bmc microbiology
Year 2009
DOI
10.1186/1471-2180-9-243
URL
https://sciprofiles.com/publication/view/e74b917333c8d40f7cf3d10f70c5b869
Keywords
survival confidence wolbachia promising endosymbiotic ranked wbm brugia malayi gene is essential

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