Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells

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ID: 268429
1997
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Abstract
We have produced transgenic mice whose livers express a dominant positive NH2-terminal fragment of sterol regulatory element binding protein-1c (SREBP-1c). Unlike full-length SREBP-1c, the NH2-terminal fragment enters the nucleus without a requirement for proteolytic release from cell membranes, and …
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h1997theisoform Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL
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Journal The Journal of clinical investigation
Year 1997
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9062341##article-details
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE genetic Mice Molecular Inbred C57BL RNA animals humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't male exons P.H.S. Cells Cultured plasmids polymerase chain reaction Immunoblotting Body Weight DNA-Binding Proteins / metabolism* Nuclear Proteins / metabolism* Receptors Liver / pathology DNA-Binding Proteins / genetics* Gene Expression Regulation* Liver / metabolism* Nuclear Proteins / genetics* transcription messenger / metabolism electrophoresis transgenic cloning nucleic acid hybridization blotting messenger / analysis transfection alternative splicing triglycerides / metabolism isomerism down-regulation northern cell nucleus / metabolism transcription factors* sterol regulatory element binding protein 1 biological transport polyacrylamide gel j l goldstein ccaat-enhancer-binding proteins* pmid:9062341 PMC507891 doi:10.1172/JCI119248 H Shimano J D Horton Acetyl-CoA Carboxylase / genetics Acetyl-CoA Carboxylase / metabolism Cholesterol / metabolism DNA-Binding Proteins / immunology Fatty Acid Synthases / genetics Fatty Acid Synthases / metabolism Glyceraldehyde-3-Phosphate Dehydrogenases / analysis Luciferases / metabolism Nuclear Proteins / immunology LDL / genetics LDL / metabolism Ribonucleases / metabolism

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