Bmi-1 collaborates with c-Myc in tumorigenesis by inhibiting c-Myc-induced apoptosis via INK4a/ARF
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ID: 268382
1999
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Abstract
The bmi-1 and myc oncogenes collaborate strongly in murine lymphomagenesis, but the basis for this collaboration was not understood. We recently identified the ink4a-ARF tumor suppressor locus as a critical downstream target of the Polycomb-group transcriptional repressor Bmi-1. Others have shown th …
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| Reference Key |
jj1999genesbmi-1
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|---|---|
| Authors | Jacobs JJ;Scheijen B;Voncken JW;Kieboom K;Berns A;van Lohuizen M;; |
| Journal | genes & development |
| Year | 1999 |
| DOI |
DOI not found
|
| URL | |
| Keywords |
National Center for Biotechnology Information
NCBI
NLM
MEDLINE
Mice
gene expression
animals
pubmed abstract
nih
national institutes of health
national library of medicine
female
male
Cells
Cultured
Genes
Knockout
Nuclear Proteins / genetics*
lymphoma
proteins / genetics*
apoptosis / genetics*
cell transformation
proto-oncogene proteins / genetics*
down-regulation
heterozygote
myc*
Tumor Suppressor Protein p14ARF
mutant strains
repressor proteins*
neoplastic / genetics
pmid:10541554
pmc317101
doi:10.1101/gad.13.20.2678
j j jacobs
b scheijen
m van lohuizen
cocarcinogenesis
bcl-2
p16*
b-cell / etiology*
b-cell / genetics*
b-cell / pathology
polycomb repressive complex 1
|
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