Levosimendan use in patients with acute heart failure and reduced ejection fraction with or without severe renal dysfunction in critical cardiac care units: a multi-institution database study - Annals of Intensive Care

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ID: 267535
2021
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Resumo
Background Acute heart failure is a life-threatening clinical condition. Levosimendan is an effective inotropic agent used to maintain cardiac output, but its usage is limited by the lack of evidence in patients with severely abnormal renal function. Therefore, we analyzed data of patients with acute heart failure with and without abnormal renal function to examine the effects of levosimendan. Methods We performed this retrospective cohort study using data from the Chang Gung Research Database (CGRD) of Chang Gung Memorial Hospital (CGMH). Patients admitted for heart failure with LVEF ≤ 40% between January 2013 and December 2018 who received levosimendan or dobutamine in the critical cardiac care units (CCU) were identified. Patients with extracorporeal membrane oxygenation (ECMO) were excluded. Outcomes of interest were mortality at 30, 90, and 180 days after the cohort entry date. Results There were no significant differences in mortality rate at 30, 90, and 180 days after the cohort entry date between the levosimendan and dobutamine groups, or between subgroups of patients with an estimated glomerular filtration rate (eGFR) ≥ 30 mL/min/1.73 m2 and eGFR 
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chan2021annalslevosimendan Use esta chave para citacao automatica no manuscrito ao usar SciMatic Gerenciador de Manuscritos ou Gerenciador de Teses
Autores Cze-Ci Chan;Kuang-Tso Lee;Wan-Jing Ho;Yi-Hsin Chan;Pao-Hsien Chu;Cze-Ci Chan;Kuang-Tso Lee;Wan-Jing Ho;Yi-Hsin Chan;Pao-Hsien Chu;
Periodico annals of intensive care
Ano 2021
DOI
doi:10.1186/s13613-021-00810-y
URL
https://dx.doi.org/10.1186%2Fs13613-021-00810-y
Palavras-chave
anesthesiology emergency medicine intensive / critical care medicine anesthesiology emergency medicine intensive / critical care medicine

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