Food groups associated with immune-mediated inflammatory diseases: a Mendelian randomization and disease severity study

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2021
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Abstract
Immune-mediated inflammatory diseases (IMIDs) are prevalent diseases. There is, however, a lack of understanding of the link between diet and IMIDs, how much dietary patterns vary between them and if there are food groups associated with a worsening of the disease. To answer these questions we analyzed a nation-wide cohort of n = 11,308 patients from six prevalent IMIDs and 2050 healthy controls. We compared their weekly intake of the major food categories, and used a Mendelian randomization approach to determine which dietary changes are caused by disease. Within each IMID, we analyzed the association between food frequency and disease severity. After quality control, n = 11,230 recruited individuals were used in this study. We found that diet is profoundly altered in all IMIDs: at least three food categories are significantly altered in each disease (P 
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Authors Antonio Julià;Sergio H. Martínez-Mateu;Eugeni Domènech;Juan D. Cañete;Carlos Ferrándiz;Jesús Tornero;Javier P. Gisbert;Antonio Fernández-Nebro;Esteban Daudén;Manuel Barreiro-de Acosta;Carolina Pérez;Rubén Queiró;Francisco Javier López-Longo;José Luís Sánchez Carazo;Juan Luís Mendoza;Mercedes Alpéri;Carlos Montilla;José Javier Pérez Venegas;Fernando Muñoz;Santos Castañeda;Adrià Aterido;María López Lasanta;Sara Marsal;Antonio Julià;Sergio H. Martínez-Mateu;Eugeni Domènech;Juan D. Cañete;Carlos Ferrándiz;Jesús Tornero;Javier P. Gisbert;Antonio Fernández-Nebro;Esteban Daudén;Manuel Barreiro-de Acosta;Carolina Pérez;Rubén Queiró;Francisco Javier López-Longo;José Luís Sánchez Carazo;Juan Luís Mendoza;Mercedes Alpéri;Carlos Montilla;José Javier Pérez Venegas;Fernando Muñoz;Santos Castañeda;Adrià Aterido;María López Lasanta;Sara Marsal;
Journal European journal of clinical nutrition
Year 2021
DOI
doi:10.1038/s41430-021-00913-6
URL
https://doi.org/10.1038/s41430-021-00913-6
Keywords
Autoimmune Diseases nutrition Epidemiology Autoimmune Diseases nutrition public health internal medicine metabolic diseases general clinical nutrition medicine/public health

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