Comparison of the activities of zanamivir, oseltamivir, and RWJ-270201 against clinical isolates of influenza virus and neuraminidase inhibitor-resistant variants

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ID: 267165
2001
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Abstract
RWJ-270201 is a novel cyclopentane inhibitor of influenza A and B virus neuraminidases (NAs). We compared the ability of RWJ-270201 to inhibit NA activity of clinical influenza isolates and viruses with defined resistance mutations with that of zanamivir and oseltamivir carboxylate. In NA inhibition …
Reference Key
lv2001antimicrobialcomparison Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gubareva LV;Webster RG;Hayden FG;;
Journal Antimicrobial agents and chemotherapy
Year 2001
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/11709315
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't u.s. gov't Comparative Study P.H.S. drug resistance microbial enzyme inhibitors / pharmacology* antiviral agents / pharmacology* substrate specificity cyclopentanes / pharmacology* influenza a virus / drug effects pmid:11709315 pmc90844 doi:10.1128/aac.45.12.3403-3408.2001 l v gubareva r g webster f g hayden acetamides / pharmacology* acids carbocyclic guanidines influenza b virus / drug effects neuraminidase / antagonists & inhibitors* neuraminidase / metabolism orthomyxoviridae / drug effects* oseltamivir pyrans sialic acids / pharmacology* zanamivir

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