Suboptimal aminoglycoside dosing in critically ill patients

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ID: 266496
2008
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Abstract
Maximal aminoglycoside (AG) killing requires that the ratio of peak serum concentrations (Cmax) to the minimum inhibitory concentration (MIC) of the pathogen exceeds by > or =10. This has been shown to hasten resolution of infection in the general patient population. It was postulated that critic …
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Authors Rea RS;Capitano B;Bies R;Bigos KL;Smith R;Lee H;;
Journal Therapeutic drug monitoring
Year 2008
DOI
DOI not found
URL
https://www.ncbi.nlm.nih.gov/pubmed/19057371
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support adult female male N.I.H. Extramural adolescent aged middle aged 80 and over Bacterial anti-bacterial agents / therapeutic use drug resistance bacteria / drug effects microbial sensitivity tests anti-bacterial agents / administration & dosage* dose-response relationship drug intensive care units bacterial infections / drug therapy critical illness anti-bacterial agents / pharmacokinetics* gentamicins / therapeutic use pmid:19057371 doi:10.1097/ftd.0b013e31818b6b2f rhonda s rea blair capitano howard lee anti-bacterial agents / blood gentamicins / administration & dosage* gentamicins / blood gentamicins / pharmacokinetics* tobramycin / administration & dosage* tobramycin / blood tobramycin / pharmacokinetics* tobramycin / therapeutic use

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