Polycystic ovary syndrome: evidence for reduced sensitivity of the gonadotropin-releasing hormone pulse generator to inhibition by estradiol and progesterone

Clicks: 317
ID: 266131
1998
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Abstract
Plasma LH is commonly elevated in women with the polycystic ovary syndrome (PCOS), but the underlying mechanisms are uncertain. We tested the hypothesis that the elevated LH in part reflects a reduced sensitivity of the hypothalamic GnRH pulse generator to suppression by estradiol (E2) and progester …
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Authors Pastor CL;Griffin-Korf ML;Aloi JA;Evans WS;Marshall JC;;
Journal the journal of clinical endocrinology and metabolism
Year 1998
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/9467578
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support u.s. gov't adult female luteinizing hormone / blood polycystic ovary syndrome / physiopathology* P.H.S. j c marshall follicle stimulating hormone / blood dose-response relationship drug kinetics progesterone / blood periodicity luteinizing hormone / metabolism hypothalamus / metabolism* pmid:9467578 doi:10.1210/jcem.83.2.4604 c l pastor m l griffin-korf estradiol / administration & dosage estradiol / pharmacology* gonadotropin-releasing hormone / metabolism* hypothalamus / drug effects* progesterone / administration & dosage progesterone / pharmacology*

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