Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

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ID: 266024
2009
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Authors Bart Ferwerda,Santos Alonso,Kathy Banahan,Matthew McCall,Evangelos J. Giamarellos-Bourboulis,Bart P. Ramakers,Maria Mouktaroudi,Pamela R. Fain,Neskuts Izagirre,Din Syafruddin,Tudor Cristea,Frank Mockenhaupt,Marita Troye-Blomberg,Oliver Kumpf,Boubacar Maiga,Amagana Dolo,Ogobara Doumbo,Santhosh Sundaresan,George Bedu-Addo,Reinout van Crevel,Lutz Hamann,Djin-Ye Oh,Ralf R. Schumann,Leo A. B. Joosten,Concepcion de la Rúa,Robert Sauerwein,Joost P. H. Drenth,Bart-Jan Kullberg,André J. A. M. van der Ven,Adrian V. Hill,Peter Pickkers,Jos W. M. van der Meer,Luke A. J. O'Neill,Mihai G. Netea;Bart Ferwerda;Santos Alonso;Kathy Banahan;Matthew McCall;Evangelos J. Giamarellos-Bourboulis;Bart P. Ramakers;Maria Mouktaroudi;Pamela R. Fain;Neskuts Izagirre;Din Syafruddin;Tudor Cristea;Frank Mockenhaupt;Marita Troye-Blomberg;Oliver Kumpf;Boubacar Maiga;Amagana Dolo;Ogobara Doumbo;Santhosh Sundaresan;George Bedu-Addo;Reinout van Crevel;Lutz Hamann;Djin-Ye Oh;Ralf R. Schumann;Leo A. B. Joosten;Concepcion de la Rúa;Robert Sauerwein;Joost P. H. Drenth;Bart-Jan Kullberg;André J. A. M. van der Ven;Adrian V. Hill;Peter Pickkers;Jos W. M. van der Meer;Luke A. J. O'Neill;Mihai G. Netea;
Journal proceedings of the national academy of sciences
Year 2009
DOI
10.1073/pnas.0811273106
URL
https://sciprofiles.com/publication/view/e82435370e81f6fa9a9b0a67c191aaa3
Keywords
cytokines evolution innate immunity tlr4 tlr2

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