Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres.
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ID: 265407
2020
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Abstract
Thiazolidinones were prepared as building blocks for the replacement of carboxylic acids. Chemical syntheses of thiazolidinones were developed. In addition, the drug-likeness of the target compounds was evaluated . The prepared compounds included the novel structure ; 5-(3-Iodophenylmethylene)-2,4-thiazolidinedione. Exploration of the methods required to synthesize thiazolidinone building blocks was completed. This work allows future generation of bioisosteric analogs of drugs.
| Reference Key |
scanlon2020unearthingfuture
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| Authors | Scanlon, James J;Wren, Stephen P; |
| Journal | Future medicinal chemistry |
| Year | 2020 |
| DOI |
10.4155/fmc-2020-0192
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