Unearthing novel thiazolidinone building blocks as carboxylic acid bioisosteres.

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ID: 265407
2020
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Abstract
Thiazolidinones were prepared as building blocks for the replacement of carboxylic acids. Chemical syntheses of thiazolidinones were developed. In addition, the drug-likeness of the target compounds was evaluated . The prepared compounds included the novel structure ; 5-(3-Iodophenylmethylene)-2,4-thiazolidinedione. Exploration of the methods required to synthesize thiazolidinone building blocks was completed. This work allows future generation of bioisosteric analogs of drugs.
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scanlon2020unearthingfuture Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Scanlon, James J;Wren, Stephen P;
Journal Future medicinal chemistry
Year 2020
DOI
10.4155/fmc-2020-0192
URL
Keywords
thiazolidinone bioisostere building blocks carboxylic acid

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