Synthesis of metronidazole based thiazolidinone analogs as promising antiamoebic agents

Clicks: 177
ID: 265381
2020
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Ranked #54 of 67 articles by views in bioorganic and medicinal chemistry letters

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Abstract
Metronidazole and its derivatives are widely used for the treatment of amoebiasis. However, metronidazole is considered as the standard drug but it has many side effects. The present study describes the synthesis of a series of metronidazole based thiazolidinone analogs via Knoevenagel condensation of 4-[2-(2-methyl-5-nitro-1H-imidazole-1-yl)ethoxy]benzaldehyde 1 with various thiazolidinone derivatives 2-14 to get the new scaffold (15-27) having better activity and lesser toxicity. Six compounds have shown better efficacy and lesser cytotoxicity than the standard drug metronidazole towards HM1: IMSS strain of Entamoeba histolytica. These compounds may combat the problem of drug resistance and might be effective in identifying potential alternatives for future drug discovery against EhOASS.
Reference Key
ansari2020synthesisbioorganic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ansari, M.F.
Journal bioorganic and medicinal chemistry letters
Year 2020
DOI
10.1016/j.bmcl.2020.127549
URL
Keywords Keywords not found

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