Vaccine Production to Protect Animals Against Pathogenic Clostridia.

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ID: 265143
2019
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Abstract
is a broad genus of anaerobic, spore-forming, rod-shaped, Gram-positive bacteria that can be found in different environments all around the world. The genus includes human and animal pathogens that produce potent exotoxins that cause rapid and potentially fatal diseases responsible for countless human casualties and billion-dollar annual loss to the agricultural sector. Diseases include botulism, tetanus, enterotoxemia, gas gangrene, necrotic enteritis, pseudomembranous colitis, blackleg, and black disease, which are caused by pathogenic . Due to their ability to sporulate, they cannot be eradicated from the environment. As such, immunization with toxoid or bacterin-toxoid vaccines is the only protective method against infection. Toxins recovered from cultures are inactivated to form toxoids, which are then formulated into multivalent vaccines. This review discusses the toxins, diseases, and toxoid production processes of the most common pathogenic species, including , , , , , and
Reference Key
zaragoza2019vaccinetoxins Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zaragoza, Nicolas E;Orellana, Camila A;Moonen, Glenn A;Moutafis, George;Marcellin, Esteban;
Journal Toxins
Year 2019
DOI
E525
URL
Keywords
fermentation clostridium toxoids clostridia diseases vaccine production

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