Combined Photoredox/Enzymatic C-H Benzylic Hydroxylations Rick C. Betoria, Catherine M. Maya, Karl A. Scheidt*a.

Clicks: 188
ID: 26434
2019
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Ranked #152 of 192 articles by views in angewandte chemie (international ed in english)

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Abstract
Chemical transformations that install heteroatoms into C-H bonds are of significant interest because they streamline the construction of value-added small molecules. Direct C-H oxyfunctionalization, or the one step conversion of a C-H bond to a C-O bond, could be a highly enabling transformation due to the prevalence of the resulting enantioenriched alcohols in pharmaceuticals and natural products,. Here we report a single-flask photoredox/enzymatic process for direct C-H hydroxylation that proceeds with broad reactivity, chemoselectivity and enantioselectivity. This unified strategy advances general photoredox and enzymatic catalysis synergy and enables chemoenzymatic processes for powerful and selective oxidative transformations.
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scheidt2019combinedangewandte Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Scheidt, Karl;Betori, Rick;May, Catherine;
Journal angewandte chemie (international ed in english)
Year 2019
DOI
10.1002/anie.201909426
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